Early in his career, Perlmutter met his wife Laurie J. Perlmutter at a Catskills resort and they married soon after.
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in 1993, Perlmutter and his wife established the Laura and Isaac Perlmutter Professorship and Chair in Cell Biology at the Skirball Institute of Biomolecular Medicine (part of the New York University School of Medicine).
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IN 2004, Avi Arad introduced Maisel to Isaac Perlmutter who hired Maisel as Marvel Studios Chief Operating Officer do to his idea for Marvel to create their own film studio.
AS of September 2006, Turitizin was appointed Executive Vice President, Office of the Chief Executive together with David Maisel, and Isaac Perlmutter (CEO).