Isaac Grier Strain was born March 4, 1821, in Roxbury, Franklin County, Pennsylvania, of Scots-Irish origin, and died May 14, 1857, in Aspinwall, (alternative name of Colón, Panama) Colombia.
He ordered U.S. Navy Lieutenant Isaac Strain to command a U.S. Darién Exploring Expedition to map and survey the Darién Gap for a Panama Canal to link the Atlantic and Pacific Oceans.
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