In 1976, he wrote, "Zionism is in its foundation racist because the state of Israel is built upon an apartheid system, exactly like South Africa".
Meshoe has argued against claims that Israel is an apartheid state, calling such accusations slanderous and deceptive.
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He argues that an apartheid system is already in place, with the West Bank and Gaza Strip separated into "cantons," and Palestinians required to carry permits to travel between them.