It is known that cases of the syndrome had already been observed during the Middle Ages, since it was described in the itinerary of Felix Fabri and the biography of Margery Kempe.
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For example, an affected person may believe himself to be an important historical religious figure or may be influenced by important religious ideas or concepts (such as causing the coming of the Messiah or the second coming of Christ).
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In The Simpsons episode "The Greatest Story Ever D'ohed", the Simpsons travel to Israel where Homer is struck with the Jerusalem Syndrome.
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