He became involved with the work being performed among the area's American Indian tribes by Isaac McCoy, joining the McCoy mission to the Wea peoples in northern Indiana in 1819.
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In 1843 Lykins founded a mission among the Potawatomi near Topeka, Kansas.
Joseph E. Johnston | Daniel Johnston | Ben Johnston | Albert Sidney Johnston | Ollie Johnston | Johnston Forbes-Robertson | Johnston Atoll | Ben Johnston (composer) | Antony Johnston | Levi Johnston | Johnston | Joe Johnston | Herbert Johnston | Freedy Johnston | David Johnston | Robin Knox-Johnston | Lynn Johnston | Lawrence Johnston | Kristen Johnston | John Taylor Johnston | Henry Halcro Johnston | Edward Johnston | Daryl Johnston | Bennett Johnston | John Johnston | Henry S. Johnston | Guy Johnston | Gillett & Johnston | Brian Johnston | Will Johnston |
McCoy, his son John, his daughter Delilah and her missionary husband Johnston Lykins, worked together as missionaries to the Shawnee and Lenape (Delaware), following them to what is now Kansas City, Missouri, on the border of Indian Territory and near their reservations.