Juan Pardo with a force of 125 Spaniards visited Cofitachequi (which he also called Canosi) on two expeditions between 1566 and 1568.
Juan Pardo de Tavera (1472–1545), Spanish cardinal and Grand Inquisitor
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At Joara, near Morganton, North Carolina, Native Americans of the Mississippian culture interacted with Spanish explorers of the Juan Pardo expedition, who built a base there in 1567 called Fort San Juan.