Gramberg attended university at Halle, where he studied Hebrew Bible and Theology under Wilhelm Gesenius and Julius Wegscheider.
In 1805 he was repentant at the University of Göttingen with a dissertation titled Graecorum mysteriis religioni non obtrudendis, he then served as a professor of theology at the University of Rinteln (1806–1810), and at the University of Halle from 1810 onwards.
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