Its story is detailed in the instruction booklet: Palutena has a nightmare, which a soothsayer interprets as a foreshadowing of an invasion by the demon Orcos and his minions.
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The story of Kid Icarus: Of Myths and Monsters is influenced by Greek mythology, and follows the angel soldier Pit on his quest for three sacred treasures.
However, it turns out that Medusa was a fake leader revived by the true Lord of the Underworld: Hades.
Kid Rock | Billy the Kid | The Karate Kid (1984 film) | Icarus | Butch Cassidy and the Sundance Kid | The Karate Kid | Kid Ory | Alex da Kid | Kid A | Sundance Kid | Kid Montana | Kid Galahad | Kid Creole and the Coconuts | Kid Carpet | Kid Auto Races at Venice | Ḳid. | I Know My Kid's a Star | The Tap Dance Kid | Star Wars Kid | Star Kid | Kid 'n Play | Kid British | Karate Kid | Icarus (mythology) | Diary of a Wimpy Kid | The Sheriff and the Satellite Kid | The Kid with the Broken Halo | The Hot Kid | The Clitheroe Kid | The Butterfly Kid |
Simon Belmont and Mega Man were appropriately replaced by Samus Aran, the Metroid heroine who had not appeared in the cartoon, and Mother Brain's second-in-command became Uranos, the demigod from Kid Icarus.