Its story is detailed in the instruction booklet: Palutena has a nightmare, which a soothsayer interprets as a foreshadowing of an invasion by the demon Orcos and his minions.
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The story of Kid Icarus: Of Myths and Monsters is influenced by Greek mythology, and follows the angel soldier Pit on his quest for three sacred treasures.
Kid Rock | Billy the Kid | The Karate Kid (1984 film) | Icarus | Butch Cassidy and the Sundance Kid | Monsters, Inc. | The Karate Kid | River Monsters | Gods and Monsters | Percy Jackson: Sea of Monsters | Universal Monsters | Monsters of Rock | Kid Ory | Alex da Kid | Walking with Monsters | Monsters University | Kid A | Famous Monsters of Filmland | Sundance Kid | Percy Jackson: Sea of Monsters (film) | Myths of the Near Future (album) | Kid Montana | Kid Galahad | Kid Creole and the Coconuts | Kid Carpet | Kid Auto Races at Venice | Ḳid. | I Know My Kid's a Star | Destroy All Monsters | Aaahh!!! Real Monsters |
However, it turns out that Medusa was a fake leader revived by the true Lord of the Underworld: Hades.
Simon Belmont and Mega Man were appropriately replaced by Samus Aran, the Metroid heroine who had not appeared in the cartoon, and Mother Brain's second-in-command became Uranos, the demigod from Kid Icarus.