In 1885 he procured the signature of a treaty with the Sultan of Bambao, thus establishing a basis for a "Grande Comore protectorate".
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On the island of Grande Comore, Humblot founded a colonial company that oversaw the operations of several farms, plantations and processing factories for spices and perfumes.
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During the following year, the French had overall rule of the Comoros (Grande Comore, Anjouan, Mayotte and Moheli islands).
Following excess by French adventurer Léon Humblot against Comorian people, the French Navy intervened in the archipelago and imposed the French administration.
Leon Trotsky | León | Kings of Leon | Nuevo León | Leon Russell | León, Guanajuato | Jean-Léon Gérôme | Kingdom of León | Leon | Saint-Pol-de-Léon | Leon René | Leon Lai | Léon Blum | Leon Redbone | León, Nicaragua | Angelu de Leon | Province of León | Leon County, Florida | Leon Battista Alberti | León, Spain | Leon Panetta | Kings Of Leon | Juan Ponce de León | André Leon Talley | Oscar D'León | Leon Ware | Leon Morris | León Gieco | Leon Dewan | Leon Botstein |
Milne-Edwards also described at least one plant taxon; a species of gutta-percha collected from the island of Grande Comore, Comoros by ornithologist Léon Humblot, which Milne-Edwards named Isonandra gutta.