Madonna with Child and Saints is the title of several works by Italian Renaissance artist Luca Signorelli.
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His last works, characterized by a cold monumental style, include a fresco with Stories of St. Anthony of Padua for the church of Sant'Angelo, a canvas with Madonna with Child and Saints for the parish church of Bioggio (Canton Ticino) and an altarpiece with St. Ambrose between Sts. Gervasius and Protasius in the Duomo of Milan (1592, now in the Pinacoteca Ambrosiana).
The name Definitorio refers to the Capitular Hall (1498), on whose end wall is a fresco of Madonna with Child and Saints by Matteo Ripanda (16th century); the hall houses a small museum of Sacred Arts, with works by Segna di Bonaventura (Madonna with Child), the Master of Monte Oliveto (Maestà ), Neroccio di Bartolomeo (St. Bernardino), Vincenzo Tamagni (Madonna with Child) and a fresco portraying St. Sebastian by an artist of the Sienese School.