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He was ordained in 1500 and held several livings before receiving his first diplomatic mission to arrange a commercial treaty with the archduke of Austria in 1504, and in the Low Countries in 1506 in connection with the projected marriage between Henry VII and Margaret of Savoy.
She died in Miranda de Ebro in 1655, her daughter Duchess Maria of Rethel and Montferrat surviving her, with two grandchildren, of whom the daughter Eleanor had in 1651 become the Holy Roman Empress and the son Charles in 1637 the reigning duke of Mantua.