In 1869, as a medical adviser of the Royal House, he assisted in childbirth Princess Margherita, Umberto I's wife and future queen, who gave birth to Victor Emmanuel III.
For the City of Benevento, he completed three busts: Vittorio Emanuele II, Prince Umberto, and Margherita of Savoy, now in the Palazzo di Paolo V.
It was named in 1896 as Lake Margherita by the Italian explorer Vittorio Bottego, the first European to visit the lake, to honor the wife of king Umberto I of Italy, Queen Margherita.
Margherita of Savoy (1851-1926), queen consort of King Umberto I of Italy
It was given this name in 1879 in honour of Queen Margherita of Savoy, who had an important love affair in the town; previously it had been known as Saline di Barletta.
From historical records, it is not quite clear whether the directors of that company renamed the place as a lasting tribute to that Italian engineer or was it Paganini himself, out of patriotism, christened the place in honour of Queen Margherita, the reigning Queen Consort of Italy.
He made a tryptich of sardonyx cameos to celebrate the family of the Queen Margherita of Savoy: the first depicts the monument raised in Turin for the Prince Ferdinand, Duke of Genoa (Queen's father), the other an equestrian statue of King Victor Emmanuel II of Italy, father of the then present king; and the third medal was the portrait of the then Prince of Naples, later King Victor Emmanuel III of Italy.
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He completed portraits, in miniature on ivory, of Vittorio Emanuele II, King Umberto I, Queen Margherita, Princess Elisabetta, Duchess of Genoa, and Prince of Naples.