Only one project, conducted on Aneityum, a small isolated island in the Pacific, succeeded in permanently interrupting transmission using MDA as one of several malaria-control strategies.
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In Southeast Asia, the medicated salt project at Pailin, on the Kampuchea-Thai border, demonstrated how drug resistance can develop when a large population of P. falciparum undergoing high transmission rates is exposed to intense drug pressure.
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In 1984, MDA was added to the distribution of insecticide-impregnated bed nets (ITNs) in Sabah (Malaysia), but this failed to interrupt malaria transmission.
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The only reported project with an MDA component which succeeded in permanently interrupting malaria transmission took place on the island of Aneityum, Vanuatu.
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