Joe Stanco, one of the founding members of the group, died of malignant melanoma on June 5, 2002 bringing an end to Victor Dada's reign as one of Dallas' top performance poetry groups.
Bob Marley's death was caused by acral lentiginous melanoma present under one of his toenails.
In a pilot study (phase I trial) at Duke Comprehensive Cancer Center, ADH-1 intravenous pretreatment before chemotherapy in metastatic melanoma completely destroyed tumors in half the patients, normally a very deadly cancer.
Tumor depth is one of the cornerstones of the current AJCC TNM staging of malignant melanoma.
CSPG4 (melanoma-associated chondroitin sulfate proteoglycan, NG2)
Cross-presentation has been shown to play a role in the immune defense against many viruses (herpesvirus, influenzavirus, CMV, EBV, SIV, papillomavirus, and others), bacteria (listeria, salmonella, E. coli, M. tuberculosis, and others) and tumors (brain, pancreas, melanoma, leukemia, and others).
In the fall of 2006, the ABC show Extreme Makeover: Home Edition traveled to Dundee to build a house for the Koepke family after Matt Koepke was diagnosed with melanoma.
In particular, increased hepatic local metastasis of B16F1 melanoma cells is observed following exogenous IL-1a administration, which results from an increased vascular adhesion receptor expression, including E-selectin, VCAM-1 and ICAM-1, and tumor cell arrest in terminal portal venules.
In recognition of his national contributions to the field of early detection and prevention of melanoma, the Boston Red Sox designated him a “Medical All Star” (2003) which included the ceremonial first pitch at Fenway Park.
Cerney died in Nashville, Tennessee on March 14, 2011 from melanoma, a disease with which he had first been diagnosed with in November 2010, following a brain seizure.
The most important genetic alteration associated with poor prognosis in uveal melanoma is inactivation of BAP1, which most often occurs through mutation of one allele and subsequent loss of an entire copy of Chromosome 3 (Monosomy 3) to unmask the mutant copy.