Offerings include RNA, MicroRNA and DNA based molecular diagnostic products providing identification of genetic abnormalities associated with oncology and genetic diseases.
miR-134 is a brain-specific microRNA; in rats it is localised specifically in hippocampal neurons and may indirectly regulate synaptic development through antisense pairing with LIMK1 mRNA.
In molecular biology, mir-160 is a microRNA that has been predicted or experimentally confirmed in a range of plant species including Arabidopsis thaliana (mouse-ear cress) and Oryza sativa (rice).
In molecular biology, the microRNA miR-219 was predicted in vertebrates by conservation between human, mouse and pufferfish and cloned in pufferfish.
mir-395 is a non-coding RNA called a microRNA that was identified in both Arabidopsis thaliana and Oryza sativa computationally and was later experimentally verified.
mir-399 is a microRNA that was identified in both Arabidopsis thaliana and Oryza sativa computationally and was later experimentally verified.
The genome of Mnemiopsis leidyi appears to lack recognizable microRNAs, as well as the nuclear proteins Drosha and Pasha, which are critical to canonical microRNA biogenesis.
There is evidence that the expression of SLC45A3 is regulated by the microRNA mir-126*.
Based on this model, her research group discovered that most microRNA genes are transcribed by RNA polymerase II and that pri-miRNA processing is carried out by Drosha-DGCR8 complexes in the nucleus.