Sanders was sworn in during April, 1912 and served until January, 1913 when the Tennessee General Assembly elected educator William R. Webb, a Democrat, to succeed him, the process called for in the United States Constitution until the Seventeeh Amendment was ratified later in the decade.
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The Republican Party, which was embroiled in a power struggle between Walter P. Brownlow and Newell Sanders, initially nominated two candidates, T. Asbury Wright (Brownlow's candidate) and George Tillman (Sanders's candidate), but Wright eventually withdrew.