Nuocytes have been shown to have a lymphoid origin and a developmental pathway that is dependent upon the transcription factor RORĪ± and Notch signalling.
Wnt signaling pathway | Notch | Notch-1 | Dixville Notch, New Hampshire | Notch 3 | Hedgehog signaling pathway | Bow River pathway | Signaling System No. 5 | Plymouth Notch, Vermont | Pathway Studios | Pathway Genomics | Widescreen signaling | The Small Molecule Pathway Database | Suprascapular notch | Stony Clove Notch | Single-frequency signaling | Signaling lymphocytic activation molecule | Semaphore Flag Signaling System | Pentose phosphate pathway | Notch-2 | nodal signaling | Next Steps in Signaling | neural pathway | Markus "Notch" Persson | Low-voltage differential signaling | hedgehog signaling pathway | Franconia Notch | Dixville Notch | Crawford Notch | Akt/PKB signaling pathway |
In canonical Notch signaling, ligand proteins bind to the extracellular domain of the Notch receptor and induce the cleavage and release of the intracellular domain into the cytoplasm.