They were founded by Bernardino de Obregón (born 5 May 1540, at Las Huelgas near Burgos, Spain; died 6 August 1599, Madrid).
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This had been founded as the hospital for the Royal Court in 1529, when the Emperor Emperor Charles V decreed that this facility was no longer to move about the country with the court but was to be established at this site.
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The motherhouse was at the Convent of Our Lady of Victory on the Puerta del Sol in Madrid, adjacent to the Church of Our Lady of Good Success.
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