From 1989 to 1996, Vandekerckhove temporarly stayed in Tuscany where he was exposed to the artworks of Cimabue, Giotto and Piero della Francesca.
According to some interpretations, John VIII would be also portrayed in Piero della Francesca's Flagellation.
In 1991, he was commissioned by the Italian government to create an exhibition in tribute to the Italian artist, Piero della Francesca, for part of the celebrations on the occasion of his 500th anniversary.
He was very much inspired by painters of the Italian quattrocento, most notably the work of Piero della Francesca.
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He was most impressed with the painters of the Italian Renaissance Piero della Francesca, Masaccio and Mantegna.
Corriere della Sera | Piero Sraffa | Piero Manzoni | Piero della Francesca | Della Robbia | Castiglione della Pescaia | Piero de' Medici | Francesca Annis | Festival della Valle d'Itria | Santa Maria della Salute | San Dorligo della Valle | Giambattista della Porta | Alessandro Del Piero | Piero Scaruffi | Giovanni della Robbia | Diego Della Valle | Canto della Terra | Basilica della Santa Casa | Santa Maria della Pietà | Roman Catholic Diocese of Alessandria della Paglia | Pratica della mercatura | Pietro Della Valle | Piero Taruffi | John Della Bosca | Francesca Cuzzoni | Bartolomeo della Gatta | Andrea della Robbia | Uguccione della Faggiuola | Ugolino della Gherardesca | ''The Baptism of Christ'', by Piero della Francesca |
Leon Battista Alberti wrote his De Re Aedificatoria under Leonello's commission, and at the Ferrarese court worked artists such as Pisanello, Iacopo Bellini, Giovanni da Oriolo, Andrea Mantegna, Piero della Francesca and the Netherlandish Rogier van der Weyden.
In 2004 a multimedia installation was displayed in the house of Piero Della Francesca at Sansepolcro.