PLS is not considered hereditary when onset is in adulthood; however, juvenile primary lateral sclerosis (JPLS) has been linked to a mutation in the ALS2 gene which encodes the cell-signalling protein alsin.
primary election | primary school | Amyotrophic lateral sclerosis | multiple sclerosis | Primary school | IB Primary Years Programme | amyotrophic lateral sclerosis | Primary election | Primary School | Multiple Sclerosis | Primary isolate | New Hampshire primary | Multiple Sclerosis Society | Multiple sclerosis | Raffles Girls' Primary School | Primary source | Primary Reserve | Primary Chronicle | National Multiple Sclerosis Society | Wood End Primary School | United States Senate Democratic primary election in Pennsylvania, 2010 | United States presidential primary | Puerto Rico Republican primary, 2012 | Primary Colors (film) | Primary Colors | Post Primary Teachers' Association | Ministry for Primary Industries | lateral pass | Ivy Bank County Primary School | Common plantar digital nerves of lateral plantar nerve |
Mutations in the ALS2 gene, found on Chromosome 2, are responsible for causing Juvenile Primary Lateral Sclerosis.