Pennsylvania Hospital, the first hospital in the British American colonies, and The Academy and College of Philadelphia, the predecessor to the private University of Pennsylvania, both opened.
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The colonial administrators claimed that they had a deed dating to the 1680s in which the Lenape-Delaware had promised to sell a portion of land beginning between the junction of the Delaware River and Lehigh River (present Easton, Pennsylvania) "as far west as a man could walk in a day and a half." This purchase has become known as the Walking Purchase.
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Antes’ neighbors on the north side of the West Branch Susquehanna and west of Lycoming Creek were outside the jurisdiction of the colonial government of Pennsylvania.
After receiving the charter for the Province of Pennsylvania on March 4, 1681 from King Charles II of England, Penn appointed William Markham as Deputy Governor on April 10, 1681.