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He died in the Congo Free State at the age of 29 from tick fever, or African relapsing fever, while investigating the disease, which is caused by a spirillum that was later named Borrelia duttoni.
Ornithodros hermsi is a vector of Borrelia hermsii which can cause tick-borne relapsing fever in humans.
He entered Anderson's University (now University of Strathclyde), in 1847, but a severe attack of famine fever (either typhus or relapsing fever) that he caught while he was a pupil at St Andrews Lying-in Hospital (now Glasgow Royal Maternity Hospital), interrupted his studies, and led him to become an assistant, first to Thomas Browne of Saffron Walden in Essex, and afterwards to Edward Dudley Hudson at Littlethorpe, Cosby, near Leicester.