The Reichsdeputationshauptschluss of 1803 secularized the rest of the archbishopric, giving the Duchy of Westphalia to the Landgraviate of Hesse-Darmstadt.
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The university was founded in 1972 and is operating on behalf of the Roman Catholic Dioceses Cologne, Limburg, Mainz, Speyer and Trier.
Since 1997 the Edith Stein Retreat House of the Archdiocese of Cologne has operated at this location, using the north wing and also a large part of the west wing of the abbey.