After co-discovering the Leptin gene with Jeffrey Friedman et al. in 1994, which involved a reverse genetic/positional cloning strategy to clone ob and db, Rudolph Leibel, working with collaborators at Millennium Pharmaceuticals and colleague Streamson Chua, confirmed cloning of the leptin receptor by demonstrating that an apparent leptin receptor cloned from a choroid plexus library using leptin as ligand, mapped to a physical map that included db and fa.
Based on interviews with the parties involved, she reports that Leptin was co-discovered at Rockefeller University by Rudolph Leibel, Jeffrey Friedman, and members of their laboratories, and explains why Leibel and others were excluded by Friedman in the scientific paper that announced the discovery.
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