public domain | Domain Name System | protein domain | eminent domain | Satsuma Domain | Eminent domain | domain name | Chōshū Domain | Domain-specific language | Digital Domain | Saga Domain | ETH Domain | Domain of unknown function | Domain name system | Domain name registrar | Domain name | domain | Unrestricted domain | Tosa Domain | Public domain | Protein domain | PDZ domain | PAS domain | Methyl-CpG-binding domain | Love's Secret Domain | Kings Domain, Melbourne | Kaga Domain | EAL domain | domain theory | Domain Name System Security Extensions |
The YMNM motif beginning at tyrosine 170 in particular is critical for the recruitment of SH2-domain containing proteins, especially PI3K, Grb2 and Gads.
In molecular biology, the BPS domain (Between PH and SH2) domain is a protein domain of approximately 45 amino acids found in the adaptor proteins Grb7Grb10/Grb14.
The interaction between GAB2 and Grb2 at the cell membrane recruits another adaptor protein, the Src homology domain-containing transforming protein 1 (SHC1), before being able to recruit SH2 domain containing molecules.
The receptor then phosphorylates and subsequently recruits Insulin Receptor Substrate or IRS-1, which in turn binds the enzyme PI-3 kinase through the binding of the enzyme's SH2 domain to the pTyr of IRS.
At this position, there is a deletion in the SH2D1A gene, which codes for an SH2 domain on a signal transducing protein called SLAM-associated protein (SAP).