Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD).
The MBD of MeCP2, MBD1, MBD2, MBD4 and BAZ2 mediates binding to DNA, and in cases of MeCP2, MBD1 and MBD2, preferentially to methylated CpG.
public domain | Domain Name System | protein domain | eminent domain | Satsuma Domain | RNA-binding protein | Eminent domain | domain name | Chōshū Domain | Binding of Isaac | Domain-specific language | Digital Domain | binding | Saga Domain | ETH Domain | Domain of unknown function | Domain name system | Domain name registrar | Domain name | domain | Unrestricted domain | Tosa Domain | The Binding of Isaac | Sterol regulatory element-binding protein | Public domain | Protein domain | PDZ domain | PAS domain | methyl salicylate | Methyl-CpG-binding domain |
In the original 1952 publication, additional evidence was obtained for the structural assignment of the reaction products by applying them to a Chugaev elimination, wherein the threo isomer reacts to the cis isomer of -α-methyl-stilbene and the erythro isomer to the trans version.
Azinphos-methyl (Guthion) (also spelled azinophos-methyl) is a broad spectrum organophosphate insecticide manufactured by Bayer CropScience, Gowan Co., and Makhteshim Agan.
Bardoxolone methyl was previously being investigated by Reata Pharmaceuticals, Inc. in partnership with Abbott Laboratories and Kyowa Hakko Kirin, as an experimental therapy for advanced chronic kidney disease (CKD) in type 2 diabetes mellitus patients.
The methyl ester of calostomal was subjected to NMR spectroscopy and was identified as all-trans-16-oxohexadeca-2,4,6,8,10,12,14-heptaenoic acid.
Also available are antibodies against a specific histone modification like H3 tri methyl K4.
Scientists at Chugai discovered an erythromycin-derived motilin agonist called Mitemcinal (aka GM-611 or 3'-N-dimethyl-11-deoxy-3'-N-isopropyl-12-O-methyl-11-oxo-8,9-didehydroerythromycin.) Mitemcinal was believed to have strong prokinetic properties, similar to its parent molecule, but lack antibiotic properties.
The treated ore is introduced to a water-filled aeration tank containing surfactant such as methylisobutyl carbinol (MIBC).
CpG site - methylated sequences of DNA significant in gene regulation
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CpG Oligodeoxynucleotide - unmethylated sequences of DNA that have immunostimulatory properties
For example, histone deacetylase 1 (HDAC1) and HDAC2 can remove the activating mark histone 3 acetyl lysine 9 (H3K9Ac), then the histone methylase G9a can add methyl groups, while the histone demethylase lysine specific demethylase 1 (LSD1) can remove the activating mark H3K4me.
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.
cAMP also binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2.
Side chains of the surrounding amino acids can have an effect on the binding of the nitrogen atom, mainly three Phe can affect the methyl groups bound to the nitrogen atom (not shown in figure 2).
DMT1 expression is found to be increased in the substantia nigra of Parkinson's patients and in the ventral mesencephalon of animal models intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) - a neurotoxin widely used experimentally to produce Parkinsonian symptoms.
All of these are transcription factors with a zinc finger DNA-binding domain (known as the DM domain) and are involved in sex-specific differentiation.
Bhopal disaster, 1984 - Release of methyl isocyanate gas and other chemicals Some estimate 8,000 people died within two weeks.
The aberrant epigenetic landscape of the cancer cell is characterized by a global genomic hypomethylation, CpG island promoter hypermethylation of tumor suppressor genes, an altered histone code for critical genes and a global loss of monoacetylated and trimethylated histone H4.
Cofactor F430, F430, the prosthetic group of the enzyme methyl coenzyme M reductase
Gal4 is a modular protein consisting broadly of a DNA-binding domain and an activation domain.
Geissoschizine methyl ether is an alkalod contained in the kampo medicine Yokukansan.
Hagemann's ester, or ethyl-2-methyl-4-oxo-2-cyclohexenecarboxylate, is an organic compound that was first prepared and described in 1893 by German chemist Carl Hagemann.
Methanol is often sold as “methyl hydrate”, implying the incorrect formula CH3OH2, while the correct formula is CH3–OH.
D-Lysergic acid α-hydroxyethylamide (LSH, LAH), also known as D-lysergic acid methyl carbinolamide, is an alkaloid of the ergoline family, and occurs in various species in the Convolvulaceae (morning glory) family and some species of fungi.
The MATH domain, in molecular biology, is a binding domain that was defined originally by a region of homology between otherwise functionally unrelated domains, the intracellular TRAF-C domains of TRAF proteins and a C-terminal region of extracellular meprins A and B.
Methyl diethanolamine (N-methyl-diethanolamine), CH3N (C2H4OH)2, a chemical used for amine gas treating, also known as gas sweetening or acid gas removal, the removal of hydrogen sulphide and carbon dioxide from gases in the petrochemical industry
Human proteins MECP2 (this protein), MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD).
Trestolone (7α-methyl-19-nortestosterone) a synthetic androgen developed for male contraception
The compound methyl salicylate was first isolated (from the plant Gaultheria procumbens) in 1843 by the French chemist Auguste André Thomas Cahours (1813-1891), who identified it as an ester of salicylic acid and methanol.
The NuRD complex contains seven subunits: the histone deacetylase core proteins HDAC1 and HDAC2, the histone-binding proteins RbAp46 and RbAp48, the metastasis-associated proteins MTA1 (or MTA2 / MTA3), the methyl-CpG-binding domain protein MBD3 (or MBD2) and the chromodomain-helicase-DNA-binding protein CHD3 (aka Mi-2alpha) or CHD4 (aka Mi-2beta).
MTSL (S-(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl methanesulfonothioate) is a chemical compound which can be used as a nitroxide (amine oxide) paramagnetic spin label in protein Electron paramagnetic resonance spectroscopy experiments.
NMDA receptors are particularly important when they become overactive during withdrawal from alcohol as this causes symptoms such as agitation and, sometimes, epileptiform seizures.
CpG Oligodeoxynucleotide also known as a CpG ODN, a molecule with immunostimulatory properties.
Another example is the bicyclic OBO protecting group (4-methyl-2,6,7-trioxa-bicyclo2.2.2octan-1-yl) which is formed by the action of (3-methyloxetan-3-yl)methanol on activated carboxylic acids in the presence of Lewis acids and was developed by Elias James Corey.
Petunidin could form in the exocarp of fruits from delphinidin, with an anthocyanin flavonoid O-methyltransferase (Catechol-O-methyl transferase) catalyzing the B-ring methylation and S-Adenosyl-L-methyl-3H methionine being the methyl group donor.
This is one of several compounds used for vector control of Triatoma.
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These insects are implicated in the transmission of Chagas disease in the Americas.
Methyltransferases are also responsible for the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.
Tentoxin (cyclo(N-methyl-L-alanyl-L-leucyl-N-methyl-trans-dehydrophenyl-alanyl-glycyl)) is a natural cyclic tetrapeptide produced by phytopathogenic fungi from genus Alternaria.
Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid, its name coming from the Greek Θῆβαι, Thēbai, an ancient city in Upper Egypt.
Varespladib methyl (also known as A-002, formerly LY333013 and S-3013) is a secretory phospholipase A2 (sPLA2) inhibitor formerly under development by Anthera Pharmaceuticals as a treatment for acute coronary syndrome (ACS).
Voacangine (12-methoxyibogamine-18-carboxylic acid methyl ester) is an alkaloid found predominantly in the rootbark of the Voacanga africana tree, as well as in other plants such as Tabernanthe iboga, Tabernaemontana africana, Trachelospermum jasminoides and Ervatamia yunnanensis.