Schaefer was raised in Midlothian, Virginia, the daughter of Billie Knight (née Hehl) and William Linwood "Bill" Schaefer.
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Nikki & Sara Live, a weekly talk show television series hosted by Schaefer and Glaser, premiered on January 29, 2013, on MTV.
Tegan and Sara | Sara Bareilles | Sara Lee Corporation | William Donald Schaefer | Sara Evans | Sara | Sara Montiel | Sara Cox | Sara Paretsky | Sara Cone Bryant | Sara Sant'Ambrogio | Sara Rue | Sara Roy | Sara Ayers | Bradley E. Schaefer | Sara Tetro | Sara Teasdale | Sara Shepard | Sara Noxx | Sara Miller McCune | Sara Losh | Sara Jean Underwood | Sara Dylan | Sara Ashurbeyli | Two Mules for Sister Sara | Simi Sara | Sara Watkins | Sara Simeoni | Sara Oldfield | Sara Niemietz |
Some comedic writers and performers who did shows at Juvie Hall included Sara Schaefer, Elliott Kalan, Brock Mahan, Amanda Melson, Dan McCoy, and Rick Younger.