One of the major irritants in the early Sino-Portuguese relations was the Portuguese' proclivity to enslave Chinese children and take them to various Portuguese colonies, or to Portugal itself.
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He abolished slavery in Portugal and the Portuguese colonies in India, reorganized the army and the navy, abolished the Autos-de-fé and ended the Limpeza de Sangue (cleanliness of blood) civil statutes and their discrimination against New Christians, the Jews that had converted to Christianity, and their descendents regardless of genealogical distance, in order to escape the Portuguese Inquisition.