Belle S. Spafford (1895–1982), former president of the Relief Society
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Horatio Spafford (1828-1888), author of the hymn "It Is Well With My Soul"
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Gene Spafford (born 1956), professor of computer science at Purdue University
Although situated in a remote corner of Onondaga County, somewhat isolated by two of the Finger Lakes, residential development is expanding into the town from adjacent Skaneateles.
The lighthouse is named for its original keeper, "Spafford Barker Belyea" and the area's original United Empire Loyalist settler, "Hendrick Belyea".
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It was built in 1881, commenced operation on June 1, 1882, with Spafford Barker Belyea serving as its first keeper and later rebuilt at a slightly different location after having been damaged due to severe flooding in the 1930s.
Among notable software designed and/or supervised by Spafford include the freeware Tripwire tool coded by his student Gene Kim (Spafford was later the chief external technical advisor to the Tripwire company during their first few years), and the freeware COPS tool coded by his student Dan Farmer.
Colonel Henry Dodge was at Gratiot's Grove when the war descended upon Spafford Farm, having just sent his volunteers to their forts to resupply and recuperate.