X-Nico

2 unusual facts about Steroid


Arachnoiditis

Steroid injections, administered either intrathecally or epidurally have been linked as a cause of the disease, therefore they are generally discouraged as a treatment and may even worsen the condition.

Post viral cerebellar ataxia

Steroids may be needed for swelling (inflammation) of the cerebellum (such as from multiple sclerosis).


19-Norandrosterone

It is created as a byproduct of nandrolone via the 5-alpha reductase enzyme and is on the list of substances prohibited by the World Anti-Doping Agency since it is a detectable metabolite of nandrolone which is an anabolic steroid.

Androstenediol

4-Androstenediol, a steroid androgen which acts as a prodrug to testosterone

5-Androstenediol, a steroid androgen which is an endogenous precursor for testosterone

BALCO scandal

The former American League MVP and current player for the Cleveland Indians allegedly admitted to steroid use as well as HGH use in front of a grand jury in December 2003.

Christian Boeving

Shortly after the film's premiere at the Sundance Film Festival, MuscleTech, a bodybuilding supplement company, dropped its sponsorship of Boeving for breaching the company's rules by discussing his steroid use.

Cytochrome P450 reductase

Five missense mutations (A284P, R454H, V489E, C566Y, and V605F) and a splicing mutation in the POR genes have been found in patients who had hormonal evidence for combined deficiencies of two steroidogenic cytochrome P450 enzymes - P450c17 CYP17A1, which catalyzes steroid 17α-hydroxylation and 17,20 lyase reaction, and P450c21 21-Hydroxylase, which catalyzes steroid 21-hydroxylation.

Darrell Robinson

Robinson had begun training with Bob Kersee in 1987 and he claimed that the coach had advised him on steroid use and given him two types of tablets; Anavar and Dianabol.

Dioscorea bulbifera

These varieties contain the steroid, diosgenin, which is a principal material used in the manufacture of a number of synthetic steroidal hormones, such as those used in hormonal contraception.

Diosgenin

Diosgenin, a steroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro.

Doping in the United States

Juiced: Wild Times, Rampant 'Roids, Smash Hits & How Baseball Got Big, a 2005 book by Jose Canseco that alleged widespread steroid use in baseball (including his own)

Emmanuel Garcia

On June 2nd 2010 The New York Mets sent an official letter from Major League Baseball informing Garcia he tested positive for high levels of human chorionic gonadotropin, which is illicitly used after an anabolic steroid cycle to jump-start the body's production of testosterone .

Equipoise

Boldenone, an anabolic steroid, by the trade name Equipoise

Ergogenic use of anabolic steroids

According to sports physician John Ziegler, the first confirmed use of an anabolic steroid in an international athletic competition was at the weightlifting championships in Vienna in 1954, when the Russians weightlifters used testosterone.

In 1992, NFL football player Lyle Alzado died from brain cancer, which he said was caused by his steroid use.

Ethinyl estradiol

The first orally active semisynthetic steroidal estrogen, EE (17α-ethynylestradiol), the 17α-ethynyl analog of E2, was synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering AG in Berlin.

Etomidate

Etomidate suppresses corticosteroid synthesis in the adrenal cortex by reversibly inhibiting 11-beta-hydroxylase, an enzyme important in adrenal steroid production; it leads to primary adrenal suppression.

Game of Shadows

Fainaru-Wada and Williams conducted a two-year investigation centering on the BALCO sports nutrition center, its founder Victor Conte, and Greg Anderson, who served as a personal trainer (and alleged steroid supplier) for Bonds, Gary Sheffield, and Jason Giambi.

Genetic enhancement in athletes

As seen with past cases, including the steroid tetrahydrogestrinone THG, athletes may choose to incorporate risky genetic technologies into their training regimes.

George Rosenkranz

George Rosenkranz (born as György Rosenkranz, August 20, 1916, Budapest) is a Mexican scientist in steroid research and a professional bridge player.

Growth hormone in sports

A report from the United States House Committee on Oversight and Government Reform on steroid and growth hormone use found that the misguided use of HGH by professional athletes and entertainers was fuelling the industry peddling the drug to the general public for medically inappropriate uses.

Jervine

Jervine is a steroidal alkaloid with molecular formula C27H39NO3 which is derived from the Veratrum plant genus.

Joe Mammana

Mammana told The Columbus Dispatch that his own criminal past — convictions including aggravated assault, identity fraud, possession of illegal steroids and auto theft — inspired him to fight crime with the wealth he has gained through his businesses.

John McVicar

In 1998 he lost a libel action brought by sprinter Linford Christie over his claim that Christie was a "steroid athlete".

José Alessandro Bagio

On March 31, 2011, Bagio was tested positive for the steroid called 19-Norandrosterone, during a national race walking competition in Brazil, a year before.

Kazi Sherpa

Kazi's record was set on the South Col Route, without supplemental oxygen, without steroid drug assistance (Dexamethasone), and without Sherpa assistance or guide assistance.

Lyngstadaas syndrome

Lyngstadaas Syndrome (named after Professor Ståle Petter Lyngstadaas) is a rare liver disease involving an enzyme (steroid dehydrogenase) deficiency and dental anomalies.

Malhação

Like American soap operas, cast and characters change from year to year, but actors and characters who have stayed for long in the soap are, among others, Alexandre Slaviero whose character "Kiko" has experienced changes (he has gone from student, to bad boy, to steroid addict, to model) and Sérgio Hondjakoff, whose character Cabeção, was in the story from seventh to twelfth season.

Management of Crohn's disease

Budesonide is an oral corticosteroid with limited absorption and high level of first-pass metabolism, meaning that less quantities of steroid enter into the bloodstream.

Mariano Natalio Carrera

His urine test was confirmed to have tested positive for the steroid Clenbuterol.

Metenolone

In December 2013, Natalia Volgina was stripped of her 2013 Old Mutual Two Oceans Marathon title and received a two-year competition ban, subsequent to a final guilty verdict for using the steroid Metenolone.

Mike Krukow

Prior to Barry Bonds indictment for perjury (in late 2007) and inclusion in George J. Mitchell's report regarding steroids in Major League Baseball (released on December 13, 2007), Krukow staunchly defended Bonds against allegations of Bonds' steroid use as described in Game of Shadows (a 2006 book about performance-enhancing drug use among high level athletes).

Progesterone

An economical semisynthesis of progesterone from the plant steroid diosgenin isolated from yams was developed by Russell Marker in 1940 for the Parke-Davis pharmaceutical company (see figure to the right).

Receptor

Nuclear receptor, a receptor found within cells that is responsible for sensing steroid and thyroid hormones and certain other molecules

Steroid hormone

Once in the nucleus, the steroid-receptor ligand complex binds to specific DNA sequences and induces transcription of its target genes.

Upon steroid binding, many kinds of steroid receptor dimerize: Two receptor subunits join together to form one functional DNA-binding unit that can enter the cell nucleus.

Tony Saunders

In his controversial book, José Canseco, a teammate of Saunders in 1999, stated that Saunders' broken arm may have been a result of steroid abuse.

University of South Carolina steroid scandal

The article begins with Tommy Chaikin, a defensive lineman on the University of South Carolina football team, vividly narrating his steroid-induced experiences the day before the annual South Carolina-Clemson football game in 1987.

Weightlifting at the 2012 Summer Olympics – Men's 77 kg

Hysen Pulaku of Albania was on the original start list but was ejected from the Games after he tested positive for the banned steroid stanozolol.

William S. Johnson

William Summer Johnson (1913–1995), American chemist and steroid researcher

Ziegler

John Bosley Ziegler, an American physician who pioneered the athletic use of the steroid Dianabol


see also