PtdIns(3,4)P2 is dephophosphorylated by the phosphatase INPP4B on the 4 position of the inositol ring and by the TPTE (transmembrane phosphatases with tensin homology) family of phosphatases on the 3 position of the inositol ring.
The homologues to Ci-VSP in mammals are called Transmembrane phosphatases with tensin homology, or TPTEs.
TPTE |