X-Nico

unusual facts about phosphatase



Glucose cycle

A deficiency in glucose 6-phosphatase that disrupts the liver glucose cycle, can lead to von Gierke's disease.

Glycogenin-1

Thanks to the presence of the glucose-6-phosphatase enzyme (G6PC), the hepatocytes are capable to turn G6PC to glucose and release it to blood so as to prevent the hypoglycemia.

Glycogenolysis

The phosphate group of glucose-6-phosphate is removed by the enzyme glucose-6-phosphatase, which is not present in myocytes, and the free glucose exits the cell via GLUT2 facilitated diffusion channels in the hepatocyte cell membrane.

HisB

The hisB gene, found in the enterobacteria (such as E. coli), in Campylobacter jejuni and in Xylella/Xanthomonas encodes a protein involved in catalysis of two step in histidine biosynthesis (the sixth and eight step), namely the bifunctional Imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase.

Pasteurization

B. tuberculosis, the bacterium requiring the highest temperature to be killed of all milk pathogens is killed at all ranges of temperature and time which also denatured alkaline phosphatase.

Phosphatidate phosphatase

PPAPDC1A (PPC1A) – phosphatidic acid phosphatase type 2 domain containing 1A

Phosphatidylinositol 3-phosphate

PtdIns3P is dephosphorylated by the myotubularin family of phosphatases, on the D3 position of the inositol ring, and can be converted to PIKfyve.

Phosphatidylinositol 3,4-bisphosphate

PtdIns(3,4)P2 is dephophosphorylated by the phosphatase INPP4B on the 4 position of the inositol ring and by the TPTE (transmembrane phosphatases with tensin homology) family of phosphatases on the 3 position of the inositol ring.

PPP1R3C

Protein phosphatase-1 (PP1) participates in the regulation of a wide variety of cellular functions by reversible protein phosphorylation.


see also