Ankle monitors are designed to be tamper-resistant and can alert authorities to removal attempts, such as cutting the conductive band causing a circuit break.
For example, the proposed SSTAR will feature a combination of anti-tamper techniques that will make it difficult to get at the nuclear material, ensure that where the reactors are transported to is closely tracked, and have alarms in place that sound if attempts at entry are detected (which can then be responded to by the military).
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GrammaTech and the University of Wisconsin have been collaborating since 2001 to develop analysis, reverse-engineering, and anti-tamper tools for binary executables.