Synadenos was a close friend to his cousin, the junior emperor Michael IX Palaiologos, but after Michael's death in 1320, Michael's father, the old emperor Andronikos II (r. 1282–1328), distrusting his loyalty, sent him to the border with Serbia, as governor of Prilep.
Theodore Roosevelt | Theodore Dreiser | Theodore Sturgeon | Theodore von Kármán | Theodore Roosevelt, Jr. | Theodore Parker | Theodore Bikel | Theodore | Theodore Roosevelt National Wildlife Refuge Complex | Théodore Botrel | Charles Theodore, Elector of Bavaria | Theodore Wirth | Theodore Ushev | Theodore Robinson | Theodore of Tarsus | Theodore Edgar McCarrick | Théodore Dubois | Theodore Roethke | Theodore of Mopsuestia | Théodore Géricault | Theodore Dru Alison Cockerell | Théodore Dézamy | Theodore C. Blegen | John Theodore of Bavaria | Charles Theodore | Theodore Ziolkowski | Theodore Winthrop | Theodore Thomas | Theodore Roosevelt National Park | Theodore of Amasea |
The family reached is peak under the Palaiologan emperors in the late 13th and first half of the 14th century: John Synadenos married Theodora Palaiologina, the niece of Emperor Michael VIII Palaiologos, and served as megas stratopedarches, and his sons John and Theodore likewise held senior military commands.