Several exponents of the imperial dynasty of the Palaiologos were buried there besides Theodora: her son Constantine, Empress Irene of Montferrat and her husband Emperor Andronikos II (r. 1282–1328).
The Palaiologos emperors largely abandoned it, ruling from Blachernae and using the vaults as a prison.
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Consequently, when the city was retaken by the forces of Michael VIII Palaiologos in 1261, the Great Palace was in disrepair.
Michael VIII Palaiologos | Palaiologos | John V Palaiologos | Andronikos II Palaiologos | Manuel II Palaiologos | Graitzas Palaiologos | Andronikos IV Palaiologos | Theodore I Palaiologos | Syrgiannes Palaiologos | Constantine XI Palaiologos | Andronikos III Palaiologos |
In 1718 he published, also at Paris, two folio volumes on the imperial coinage from Trajan to the last of the Palaeologi (98-1453), Numismata Imperatorum Romanorum a Trajano Decio usque ad Palaeologos Augustos (supplement by Tanini, Rome, 1791).
Dobrotitsa supported John V Palaiologos against his son Andronikos IV Palaiologos.
After the Palaiologan usurpation of the imperial throne, both ladies (dowager empress Constance and Eudokia) fled, travelling the same route from Constantinople to Tende and Sicily respectively and, years later, both sought protection at the kingdom of Aragon under king James I.
Irene Palaiologina, Empress of Bulgaria, daughter of Michael VIII Palaiologos, Empress-consort of Bulgaria in 1279–80
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Irene Palaiologina of Trebizond, illegitimate daughter of Andronikos III Palaiologos, reigning Empress of Trebizond in 1340–41
In Assassin's Creed: Revelations (2011), Palaiologos plays a central role to the plot as one of the main antagonists.
The family reached is peak under the Palaiologan emperors in the late 13th and first half of the 14th century: John Synadenos married Theodora Palaiologina, the niece of Emperor Michael VIII Palaiologos, and served as megas stratopedarches, and his sons John and Theodore likewise held senior military commands.
Theodora Tocco, despoina consort of Constantine, Despot in Morea (later Constantine XI Palaiologos).