It was one of four cities in historic Armenia named Tigranakert.
Khosrau not only returned Dara and Martyropolis in exchange for Maurice's assistance, but also agreed to a new partition of the Caucasus by which the Sassanids handed over to the Byzantines many cities, including Tigranokert, Manzikert, Baguana, Valarsakert, Bagaran, Vardkesavan, Yerevan, Ani, Kars, and Zarisat.
From 54 AD to 68 AD the Sixth Legion Ferrata served under Gnaeus Domitius Corbulo at Artaxata and Tigranocerta against the Parthians.