His best known work is the Tropicana Club of 1951, for which he later designed expansions.
As a leading member of the syndicate, it was suspected that he also had behind-the-scenes interests in other syndicate-owned Cuban gambling casinos namely, the Hotel Habana Riviera, the Tropicana Club, the Sevilla-Biltmore, the Capri Hotel Casino, the Commodoro, the Deauville, and the Havana Hilton.
On the TV series I Love Lucy, the character Ricky Ricardo (played by Cuban-born Desi Arnaz) was a singer and bandleader at Manhattan's fictional Tropicana nightclub, now recreated in reality in Jamestown, New York at the Lucille Ball-Desi Arnaz Center's Tropicana Room.
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The history of the cabaret is detailed in Tropicana Nights: The Life and Times of the Legendary Cuban Nightclub (Harcourt, 2005) by Rosa Lowinger and Ofelia Fox.
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Within a few years, Trafficante owned or held stakes in both The Tropicana and The Sans Souci (the only casinos which had been operating in Havana for several years prior to 1955).
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Many American celebrities on vacation or who were performing at the nearby Tropicana Club visited fashionable Oriental Park Racetrack, as did Europeans such as tennis star Suzanne Lenglen.