U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
Owing to the presence of U.S. Highways 151, 61, and 52, and the nearby Dubuque Regional Airport, the area is home to a growing number of businesses.
It runs south–north in northeast Wisconsin from a junction with US 151 approximately 1.5 miles north of Brothertown near the eastern shore of Lake Winnebago in Calumet County to the Michigan State line at the Brule River approximately one mile northeast of Nelma in Forest County where it connects to M-73.