Later, U.S. Route 22 largely followed portions of the Forbes Road from Monroeville through a town now named "Forbes Road" and Hannastown to Latrobe.
The Pointe is unique in that it has an exit off one of Pittsburgh's busiest highways, I-376/US 22/US 30 (known locally as the Parkway West).
U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
Its major roads include east-to-west Highway 22, William Penn Highway, and Freemansburg Road and north-to-south Highway 33, Route 191, Butztown Road/Hecktown Road, Farmersville Road, and Main Street Extension.
The Fort Steuben Bridge, originally the Weirton-Steubenville Bridge, was a suspension bridge which spanned the Ohio River from Steubenville, Ohio to Weirton, West Virginia and carried U.S. Route 22 and then Ohio State Route 822 during its existence.
The Southern Beltway is planned to be a high-speed east-west link between the Mon–Fayette Expressway, Interstate 79, U.S. Route 22, Interstate 376, and Pittsburgh International Airport.
Its western terminus is at U.S. Route 22 in Bridgewater Township, Somerset County while its eastern terminus is at Route 27 in Elizabeth, Union County.
Highway 22 crosses it east-to-west and interchanges in the township just west of Wilson with Route 248, which connects Easton and Nazareth.
The Frankstown Branch Juniata River runs north along the west foot of the ridge before turning east along U.S. Route 22 at Water Street, the river, road, and rail (abandoned PRR Petersburg Branch) crossing the ridge line through a water gap.