U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
U.S. Route 2 crosses the town, leading west to downtown Ashland and east to Ironwood, Michigan.
US 95 goes north to Sandpoint, where it joins with US 2, after which the highways run concurrent until after Bonners Ferry, where US 2 heads east to Montana and US 95 continues north to Canada, meeting BC 95 at the border.
According to Peakbagger.com the Wenatchee Mountains are defined as bounded by U.S. Route 2 from Stevens Pass to Wenatchee on the Columbia River, then down the Columbia River to Interstate 90, then west along the highway to the vicinity of Cle Elum and Roslyn, then north along Cle Elum Lake and the Cle Elum River and north to Stevens Pass.
Other major highways in the region include U.S. Highway 302 (Wells River to Conway), New Hampshire State Route 16 (from Gorham to Conway), State Route 10 (from Littleton to Piermont), and U.S. Route 2 from Lancaster to Shelburne.
The highway proceeds west for a short distance, passing several buildings that make up the twin, before U.S. Route 2 splits off, and the Loop designation transfers to Washington State Route 20.