U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
In 1973, US 220 became a freeway between Bedford and Altoona, Pennsylvania, and the old tract of the route near Bedford became a business loop.
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Afterward, it becomes Plank Road between Hollidaysburg and Altoona, feature four-lanes, a center turning lane, and a copious commercial development.
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A cosign with Pennsylvania Route 764 occurs, as the route travels toward Tyrone, through which it serves as a narrow main street.
Lycoming Mall is a super-regional shopping mall located off Interstate 180 just west of the junction with U.S. Route 220 in the village of Halls, Muncy Township, Lycoming County ten miles east of Williamsport, Pennsylvania.
Approximately three miles south of Ridgeway in Henry County on U.S. Route 220 is a Virginia State historic marker noting the passing of the surveying party of William Byrd II, who moved through the area in 1728 on his expedition to survey the dividing line between Virginia and North Carolina.