State highways 299 and 328 intersect at the town's southern boundary, the latter connecting it with Harriman to the south and U.S. Route 27 to the north.
U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
The project will eventually replace the road all the way to U.S. Route 27 in McCreary County.
Wartburg is centered near the junction of U.S. Route 27, which connects the city to Kentucky to the north and Harriman and Interstate 40 to the south, and Tennessee State Route 62, which connects Wartburg to Oak Ridge to the east and Middle Tennessee to the west.