This roadway runs generally north-south, connecting Kings Highway (County Route 551) with U.S. Route 322.
U.S. Route 322, known as Mayfield Road in Greater Cleveland, Ohio
U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
In 1964, the West Chester Bypass was completed around this Philadelphia suburb and the prior routing of US 322 became a business loop.
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It then turns south onto Quarry Road near an interchange with U.S. Route 30, and travels west past industrial development on Boot Road.
It then enters Monroe Township, where in Williamstown, it meets U.S. Route 322 and County Route 536 Spur.
A freeway for Route 45 between Interstate 295 in Woodbury and U.S. Route 322 in Mullica Hill was recommended by the Delaware Valley Regional Planning Commission in the 1960s.