U.S. Route 66 | U.S. Route 1 | U.S. Route 6 | U.S. Route 101 | Route 66 | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | California State Route 1 | U.S. Route 1 in Maine | Pennsylvania Route 309 | European route E18 | U.S. Route 23 | European route E4 | U.S. Route 9 in New York | U.S. Route 11 | Pennsylvania Route 82 | European route E70 | U.S. Route 90 | U.S. Route 75 | U.S. Route 61 | U.S. Route 60 | Pennsylvania Route 73 | New York State Route 32 | European route E55 | U.S. Route 80 | U.S. Route 71 | U.S. Route 51 | U.S. Route 22 |
SR 389 stretches from the Utah border at Colorado City, southeast to Pipe Spring National Monument, and ends at U.S. Route 89A in Fredonia; it is the only major east–west route between these two towns, and also serves to connect Fredonia with points farther west such as St. George, Utah.