UniProt (universal protein resource) – a central repository of protein data
The largest protein database in the world, known as the UniProt database (formerly SwissProt), has shown reports of molecular mimicry becoming more common with expansion of the database.
The various sources include the scientific literature, books, government documents, and numerous external databases (such as PubChem, UniProt, PubMed, DrugBank, Human Metabolome Database (HMDB), NIST Chemistry WebBook, KEGG, NCI Database Browser, PharmGKB, Food and Drug Administration, ChEBI, and ChemExper).
This program accepts a wide range of input formats, including NBRF/PIR, FASTA, EMBL/Swiss-Prot, Clustal, GCC/MSF, GCG9 RSF, and GDE.
The nucleotide (DNA/RNA) and protein sequences of D. molleri have been sourced through the European Nucleotide Archive (ENA) and Universal Protein Resource (UniProt) databases.
The HH-suite comes with a number of useful databases of profile HMMs that can be searched using HHblits and HHsearch, among them a clustered version of the UniProt database, HMMs for the protein data bank of protein structures, for the Pfam database of protein family alignments, the SCOP database of structural protein domains, and many more.
In 2002, PIR along with its international partners, EBI (European Bioinformatics Institute) and SIB (Swiss Institute of Bioinformatics), were awarded a grant from NIH to create UniProt, a single worldwide database of protein sequence and function, by unifying the PIR-PSD, Swiss-Prot, and TrEMBL databases.