He has worked with the some of the best directors in the industry like Jayoo & Nachiket Patwardhan, Gajanan Jahgirdar, Vijaya Mehta, Mahesh Manjrekar, Raj Kumar Santoshi, Shahab Shamsi, Gajendra Ahere and Mohan Gokhale.
She is most known for her acclaimed role in film Party (1984) and for her directorial ventures, Rao Saheb (1986) and Pestonjee (1988).
Zubin Mehta | Deepa Mehta | Taarak Mehta Ka Ooltah Chashmah | Ketan Mehta | Vijaya Mehta | Tyeb Mehta | Vijaya Vani | Vijaya Mulay | Vijaya Corea | Vijaya | Sonny Mehta | Prince Vijaya | Nanji Kalidas Mehta | Ashish Mehta | Vijaya Raghava Nayak | Vijaya Bank | Suketu Mehta | Minesh Mehta | Minesh mehta | Mehta | Jehangir Mehta | Zarin Mehta | Vijaya Wimalaratne | Vijaya Rajadhyaksha | Vijaya Raghunatha Raya Tondaiman II | Vijaya (disambiguation) | Vijaya College, Bangalore | Vijaya College | Tara Mehta | Om Mehta |
Here he was associated with training many well-known film and theatre actors and directors including Vijaya Mehta, Om Shivpuri, Om Puri, Naseeruddin Shah, Manohar Singh, Uttara Baokar, Jyoti Subhash, Suhas Joshi, B. Jayashree, Jayadev and Rohini Hattangadi .
Deshpande started her career as a teacher at Chhabildas Boy's High School in Dadar, Mumbai, while working here she asked noted playwright, Vijay Tendulkar to write a few plays for her students, this started her association with theatre, and in time made one of the pioneers in experimental theatre movement of the 1960s, as she joined the group Rangayan, which was founded by Vijaya Mehta, Tendulkar, Arvind Deshpande and Shriram Lagoo.