Skeffington was the eldest son of Clotworthy John Skeffington, 11th Viscount Massereene by Florence Whyte-Melville, only daughter of Major George Whyte-Melville.
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They had one son, John Whyte-Melville-Skeffington, who succeeded as 13th Viscount.
From 1665 to 1816 the Skeffington Baronetcy of Fisherwick was attached to the viscountcy and from 1756 to 1816 the Viscounts also held the title of Earl of Massereene.
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John Clotworthy was a prominent Anglo-Irish politician during the Civil War.
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John Foster served as Chancellor of the Irish Exchequer and as Speaker of the Irish House of Commons and also represented County Louth in the British House of Commons.
Horatio Nelson, 1st Viscount Nelson | Viscount | Vickers Viscount | Bernard Montgomery, 1st Viscount Montgomery of Alamein | William Howe, 5th Viscount Howe | viscount | Garnet Wolseley, 1st Viscount Wolseley | Charles Lyttelton, 10th Viscount Cobham | William Slim, 1st Viscount Slim | Edmund Allenby, 1st Viscount Allenby | William Lamb, 2nd Viscount Melbourne | Julian Byng, 1st Viscount Byng of Vimy | Alan Brooke, 1st Viscount Alanbrooke | William Waldorf Astor, 1st Viscount Astor | James Bryce, 1st Viscount Bryce | Henry St John, 1st Viscount Bolingbroke | Henry John Temple, 3rd Viscount Palmerston | Edward Grey, 1st Viscount Grey of Fallodon | Charles Bathurst, 1st Viscount Bledisloe | Walter Runciman, 1st Viscount Runciman of Doxford | Viscount Falkland | Samuel Hood, 1st Viscount Hood | John Anderson, 1st Viscount Waverley | James Craig, 1st Viscount Craigavon | William Beresford, 1st Viscount Beresford | William Barrington, 2nd Viscount Barrington | Stapleton Cotton, 1st Viscount Combermere | Rowland Hill, 1st Viscount Hill | Marcus Samuel, 1st Viscount Bearsted | John Monckton, 1st Viscount Galway |