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Felbamate and vigabatrin are newer AEDs, but can have serious adverse effects so they are not considered first-line treatments.
Research suggested that most of the adverse effects of NSAIDs were mediated by blocking the COX1 (constitutive) enzyme, with the analgesic effects being mediated by the COX2 (inducible) enzyme.
Phosphodiesterase (PDE) inhibitors, such as theophylline, have been used to treat Chronic Obstructive Pulmonary Disease (COPD) for centuries; however, the clinical benefits of these agents have never been shown to out-weigh the risks of their numerous adverse effects.
To highlight this concern, Best Buy Drugs' doctors and editors publish drug-safety reports to draw attention to the adverse effects and risks of prescription drugs, such as Celebrex and Alli.
In aviation, pressure suits protect fighter pilots from hypoxia / altitude sickness, and g-suits from the adverse effects of acceleration (gravity-induced loss of consciousness, or G-LOC).
At least one of its species, Eufriesea purpurata from Brazil, has been shown to selectively collect large quantities of the insecticide DDT without any apparent adverse effects.
Researchers at King Feisal University state that the use of synthetic color in various foods has adverse effects on some of biochemical analysis, specifically at high concentration and when administered for long periods of time.
Smaller sized stationary receive only sites, like those used by amateurs or SMATV which have a wider beam width reception potential, may have experienced interference, while for the most part commercial operators experienced no adverse effects from Galaxy 15 during its failure period thanks to the execution of the mitigation practices devised in the wake of the crisis.
This discovery, which has drastically reduced the adverse effects and improved the efficacy of protease inhibitors and HAART, was first communicated in an article published in the journal AIDS in 1997 by researchers at the University of Liverpool.
The magnitudes and accelerations of ship motions, (particularly heave, roll and pitch) have adverse effects on passengers and shipboard personnel.
In December 2005, the federal caucus of the Australian Labor Party initiated an Industrial Relations Taskforce in order to investigate the adverse effects of the legislation, chaired by Brendan O'Connor, with special emphasis on the impact on regional and rural communities, women and young people.