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unusual facts about antibiotic


Antibiotic-associated diarrhea

Caution should, however, be exercised when administering probiotic supplements to immunocompromised individuals or patients who have a compromised intestinal barrier.


23S ribosomal RNA

A well-known member of this antibiotic class, Chloramphenicol, acts by inhibiting peptide bond formation, with recent 3D-structural studies showing two different binding sites depending on the species of ribosome.

Abraham Z. Joffe

The influence of overwintering on the antibiotic activity of several molds of the genus Cladosporium, Alternaria, Fusarium, Mucor, Thamnidium and Aspergillus. Acta Acad. Sci. Lith. SSR Ser.

Acromyrmex

In addition to feeding the fungal garden with foraged food, mainly consisting of leaves, it is protected from Escovopsis by the antibiotic secretions of Actinobacteria (genus Pseudonocardia).

Antibodies from Lymphocyte Secretions

This test is used as a complimentary test to other tests, e.g. chest X-ray, ESR, CRP, history of contact with active TB case, failure with conventional antibiotic treatment etc.

Antimicrobials in aquaculture

Antibiotic-resistant bacteria can spontaneously arise when selective pressure to survive results in changes to the DNA sequence of a bacteria allowing that bacteria to survive antibiotic treatments.

Candicidin

Candicidin is an antibiotic obtained from Streptomyces griseus and is active against some fungi of the Candida albicans.

Chugai Pharmaceutical Co.

Scientists at Chugai discovered an erythromycin-derived motilin agonist called Mitemcinal (aka GM-611 or 3'-N-dimethyl-11-deoxy-3'-N-isopropyl-12-O-methyl-11-oxo-8,9-didehydroerythromycin.) Mitemcinal was believed to have strong prokinetic properties, similar to its parent molecule, but lack antibiotic properties.

Cyathus helenae

Cyathus helenae produces a series of diterpenoid chemical compounds known as cyathins, which have antibiotic properties against the bacteria Staphylococcus aureus.

Daunorubicin

A new strain of Streptomyces peucetius which produced a red pigment was isolated, and an antibiotic was produced from this bacterium that was found to have good activity against murine tumors.

Drug discovery

The classical example of an antibiotic discovered as a defense mechanism against another microbe is the discovery of penicillin in bacterial cultures contaminated by Penicillium fungi in 1928.

DXR

Doxorubicin, an anthracycline antibiotic used in cancer chemotherapy.

Endiandra introrsa

Endiandric acid C, isolated from the Endiandra introrsa tree, is reported to have better antibiotic activity than ampicillin.

Enviomycin

Enviomycin (INN, also called tuberactinomycin N) is an antibiotic drug, isolated from Streptomyces griseoverticillatus var.

Ernest Duchesne

He made this discovery 32 years before Alexander Fleming discovered the antibiotic properties of penicillin, a substance derived from those moulds, but his research went unnoticed.

Interstitial nephritis

Common causes include infection, or reaction to medication (such as an analgesic or antibiotics such as Methicillin (Meticillin).

Kanamycin

Mammalian cells, yeast, and other eukaryotes acquire resistance to geneticin (= G418, an aminoglycoside antibiotic similar to kanamycin) when transformed with a kanMX marker.

Klebsiella pneumonia

Infections due to multidrug-resistant Gram-negative pathogens in the ICU have invoked the re-emergence of colistin, an antibiotic that had rarely been used for decades.

Lida Holmes Mattman

Her studies have concerned investigating the role of surface tension depressants in immunological systems, the first complement fixation with a bacteria-free virus, the first report of wound botulism, geotrichum mycemia, nasal carriage of Clostridium tetani, antibiotic cure of rhinoscleroma, antibiotic sensitivity testing of Coccidiodes immitis, and electron microscope studies of Peptococci.

Lidia Rudnicka

Clinical observations made by professor Rudnicka and her co-workers indicate the rationality of long-term low-dose antibiotic therapy in chronic inflammatory skin diseases: SLE and psoriasis.

Melafix

Melafix (a proprietary name) is an all-natural aquarium antibiotic consisting of an essential oil of the Melaleuca genus.

Minimum inhibitory concentration

Clinically, the minimum inhibitory concentrations are used not only to determine the amount of antibiotic that the patient will receive but also the type of antibiotic used, which in turn lowers the opportunity for microbial resistance to specific antimicrobial agents.

Patent Lens

For agriculture and the environment, landscapes exist to describe the Agrobacterium-mediated transformation of plants, promoters used to regulate gene expression, antibiotic resistance genes and their uses in plant genetic transformation, resistance to Phosphinothricin, positive selection, bioindicators/ambiosensors, and the rice genome.

Pentamycin

Pentamycin is a polyene antifungal antibiotic obtained from Streptomyces pentaticus.

Plicamycin

Plicamycin (INN, also known as mithramycin; trade name Mithracin) is an antineoplastic antibiotic produced by Streptomyces plicatus.

SLC1A2

Ceftriaxone, an antibiotic, has been shown to induce/enhance the expression of EAAT2, resulting in reduced glutamate activity.

Sparassol

Sparassol is an antibiotic/antifungal isolated from Sparassis crispa.

Spiral plater

Spiral platers are also used for research, clinical diagnostics and as a method for covering a Petri dish with bacteria before placing antibiotic discs for AST.

Teicoplanin

Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis.

Terminalia schimperiana

In laboratory experiments, extracts of the plant were found to have in vitro antibiotic properties against Staphylococcus.

The Demon under the Microscope: From Battlefield Hospitals to Nazi Labs, One Doctor’s Heroic Search for the World’s First Miracle Drug

The Demon Under the Microscope: From Battlefield Hospitals to Nazi Labs, One Doctor's Heroic Search for the World's First Miracle Drug is a 2006 nonfiction book about the discovery of Prontosil, the first commercially available antibacterial antibiotic and sulfanilamide, the first commercial antibiotic.

Vancomycin-resistant Enterococcus

Vancomycin-resistant Enterococcus, or vancomycin-resistant enterococci (VRE), are bacterial strains of the genus Enterococcus that are resistant to the antibiotic vancomycin.


see also